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The 5th Annual West Oncology Conference at Graceland: Advances in the Business and Science of Oncology Special Updates from COA, ASCO, ASH, ASTRO, and ESMO was a valuable forum for the presentation and discussion of new research findings. Participants were provided with an update on practice-changing data on women’s cancers, genitourinary malignancies, disparities in cancer care, gastrointestinal cancers, head and neck cancers, and lung cancer in a practical and interactive format, fostering discussion and impacting clinical outcomes for patients.